25 Years of p53 Research - 2007

Monday, 25 April 2016 02:51
Description: p53 has emerged as a key tumor suppressor and important target for novel cancer therapy. This book, written by world-leading p53 researchers including many of those who have shaped the field over the past 25 years, provides unique insights into the progress of the field and the prospects for better cancer diagnosis and therapy in the future.
Description: Black's Medical Dictionary first appeared in 1906. That new century was to see health care in the United Kingdom evolve from a largely personal, paternalistic consultation between doctor and patient, based more on medical tradition than medical science, to a complex, science-based, team-oriented and managed service. The emergence of the informed patient was largely responsible for this change, and publications like this dictionary, the contents of which have during its forty-one editions reflected these changes in medicine, have served as a catalyst.

The forty-first edition of Black's Medical Dictionary provides over 5,000 definitions and descriptions of medical terms and concepts, along with over 100 diagrams and drawings including several pages of color illustrations, and is accompanied by appendixes on important subjects such as the National Health Service (including selected statistics), Health Economics, Complementary and Alternative Medicine, Common Medical Tests, and an address list of support and professional organizations. Where relevant, entries contain appropriate cross-references to further information. All material has been checked and updated with new or substantially revised entries. This home compendium is invaluable for all who need an authoritative one-volume medical reference book.

Description: Diagnostic Pediatric Hematopathology is unique in providing an accurate and up-to-date guide to the diagnosis of benign and malignant hematologic disorders of childhood. The text discusses the development of the hematopoietic and lymphoid systems - and how this affects normal and abnormal findings in children at various ages. Also examined are the morphologic, immunophenotypic, cytogenetic, and molecular genetic characteristics of most pediatric-specific hematologic diseases. This is an excellent reference that ensures accurate diagnoses when evaluating peripheral blood, bone marrow, and lymph nodes of children. The text is written by a team of experienced pediatric hematopathologists and clinical scientists drawn from major academic children's hospitals in the United States, United Kingdom, and Canada. It will be a valuable tool in the every day practice of pathologists, pediatric pathologists, and hematopathologists, and a ready educational resource for fellows, pathology residents, medical students, clinical scientists in the field, and pediatric hematologists/oncologists.
Description: Determining and understanding the molecular mechanisms of disease is one of the key goals of modern medical research. The studies of medical genetics, microbiology, immunology, structural biology, molecular cell biology, neuroscience and developmental biology have been brought to bear on the full range of human diseases. This comprehensive Encyclopedia supplies the reader with concise information on molecular pathophysiology of human disease.
Entries include both defined diseases (such as Parkinson's disease) and pathophysiological entities (such as tremor). The more than 1,200 entries are structured to allow rapid retrieval of information. For more detailed reading, each entry is followed by up to 5 references. The individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved.
Description: The first part of the book focuses on indications and results of transplantation for acute leukemias, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer, providing insight into the relative merits of transplant and nontransplant approaches to these disorders. Part II examines transplant-related complications including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver.
Description: One of the best-selling medical textbooks of all time, Robbins and Cotran Pathologic Basis of Disease is the one book that nearly all medical students purchase, and is also widely used by physicians worldwide. A "who's who" of pathology experts delivers the most dependable, current, and complete coverage of today's essential pathology knowledge. At the same time, masterful editing and a practical organization make mastering every concept remarkably easy. Online access via Student Consult includes self-assessment and review questions, interactive case studies, downloadable images, videos, and a virtual microscope that lets you view slides at different magnifications. The result remains the ideal source for an optimal understanding of pathology.
  • Offers the most authoritative and comprehensive, yet readable coverage available in any pathology textbook, making it ideal for USMLE or specialty board preparation as well as for course work.
  • Includes access to the complete contents online via Student Consult, along with self-assessment and review questions, over 100 interactive clinical case studies, downloadable images, videos, and a virtual microscope that lets users view slides at different magnifications.
  • Delivers a state-of-the-art understanding of the pathologic basis of disease through completely updated coverage, including the latest cellular and molecular biology.
  • Demonstrates every concept visually with over 1,600 full-color photomicrographs and conceptual diagrams - many revised for even better quality.
  • Facilitates learning with an outstanding full-color, highly user-friendly design.
 
Description: This companion monograph to West's Respiratory Physiology covers normal respiratory function and focuses on the function of the diseased lung. Pulmonary Pathophysiology: The Essentials offers a concise overview of the diseased states of the lung, emphasizing structure and function. The Eighth Edition is updated to include new information on asthma therapies, new radiographs and micrographs, extended sections on infections and cancer, more thorough explanations for review questions, and a new summary appendix of equations with sample calculations.
 
 
 
 
 

Cytopreparation Principles Practice 2013

Monday, 25 April 2016 15:55
Description: Cytopreparation: Principles and Practice by Gary W. Gill fills a long-standing need for an easy-to-use and authoritative manual on the fundamentals of cytopreparation up-to-and- including microscopy, screening, and data analysis. The text describes in phenomenological terms the most common materials and methods of specimen collection through mounting for gyn, non-gyn, and FNA specimens, as well as the underlying mechanistic bases. The author provides his expertise and information that will empower and enable readers to review and improve their laboratories’ cytopreparatory techniques as they apply to the vast majority of specimens. This unique volume provides facts that are not readily available anywhere. Cytopreparation: Principles & Practice is intended for everyone associated with, and involved in, making cytologic preparations that are useful for their intended purpose. It will serve as a valuable reference tool for educators in cytology and histology, cytotechnology and histotechnology students, cytotechnologists, cytopreparatory technicians, cytopathologists, anatomical/clinical pathologists, pathology residents and cytopathology fellows.

Description: Based on Lever's Histopathology of the Skin, Second Edition, this full-color atlas presents an algorithmic pattern recognition approach to differential diagnosis of skin diseases. Whereas Lever's classifies diseases by pathogenesis, this atlas aids in differential diagnosis of unknown cases by classifying diseases morphologically, based on their location in the skin and the patterns and cell types seen through the microscope. Within each morphologic category, prototypic disorders are described and illustrated with full-color photomicrographs, and a list of differential diagnostic possibilities is presented. The atlas contains over 1,300 full-color illustrations.

Acetylcholine Receptor (AChR) Antibody

Written by Saturday, 23 April 2016 18:06
An acetylcholine receptor (AChR) antibody test is used to help diagnose myasthenia gravis (MG) and to distinguish it from other conditions that may cause similar symptoms, such as chronic muscle fatigue and weakness.
 
AchR antibodies hinder the action of acetylcholine, a chemical (neurotransmitter) that transmits messages between nerve cells. The antibodies do this in three major ways:
  • "Binding" antibodies attach to the acetylcholine receptors on nerve cells and may initiate an inflammatory reaction that destroys them.
  • "Blocking" antibodies may sit on the receptors, preventing acetylcholine from binding.
  • "Modulating" antibodies may cross-link the receptors, causing them to be taken up into the muscle cell and removed from the neuromuscular junction.
Three different types of tests are available to determine which of these may be the problem in a particular individual. However, the test that measures "binding" antibodies is most commonly used because it is generally rare for the other two tests to be positive without the "binding" test being positive as well. These other tests may be used when a doctor strongly suspects myasthenia gravis and the "binding" test is negative.
 
One or more of the AChR antibody tests may be ordered as part of a panel of tests that may also include a striated muscle antibody test to help establish a diagnosis. Depending upon results, an anti-MuSK (muscle-specific kinase) antibody test may also be ordered. The AChR antibody test may be ordered initially as a baseline test and then as indicated to evaluate MG disease activity and/or response to therapy.
 
People with MG often have an enlarged thymus gland and may have thymomas (typically benign tumors of the thymus). Located under the breastbone, the thymus is an active part of the immune system during childhood but normally becomes less active after puberty. If a thymoma is detected, such as during a chest computed tomography (CT) scan done for a different reason, then an AChR antibody test may sometimes be used to determine whether the person has developed these antibodies.
 
When is it ordered?
The AChR antibody test may be ordered when a person has symptoms that suggest MG, such as:
  • Drooping eyelid
  • Double vision
  • Decreased eye movement control
  • Difficulty swallowing, chewing, with choking, drooling and gagging
  • Slurred speech
  • Weak neck muscles
  • Trouble holding up head
  • Difficulty breathing
  • Difficulty walking and an altered gait
  • Specific muscle weakness but normal feelings/sensations
  • Muscle weakness that worsens with sustained effort and improves with rest
When a person has been diagnosed with MG, an AChR antibody test may be ordered occasionally to evaluate MG disease activity and/or response to therapy.
 
An AChR antibody test may sometimes be ordered when a thymoma is detected.
 
What does the test result mean?
AChR antibodies are not normally present in the blood. They are autoantibodies and their presence indicates an autoimmune response.
 
If a person has AChR antibodies and symptoms of MG, then it is likely that the person has this condition.
 
AChR antibodies may be seen with some thymomas, in people who are being treated with drugs such as penicillamine, with some small cell lung cancers, with autoimmune liver disease, and with Lambert-Eaton myasthenic syndrome (a condition associated with interference with the release of acetylcholine from the nerve ending).
 
A negative test result does not rule out MG. Up to 50% of those with ocular MG (affecting only eye-related muscles) and about 10-15% of those with generalized MG will be negative for AChR antibodies.
 
In general, the greater the quantity of AChR antibody, the more likely a person is to have significant symptoms, but the test results cannot be used to evaluate the severity of symptoms in a specific person.
Advertisement
Advertisement

Useful Sites

  • NCBI

    National Center for Biotechnology Information
  • LTO

    Lab Tests Online® by AACC
  • ASCP

    American Society for Clinical Pathology
  • ASM

    American Society for Microbiology
  • The Medical Library®

    Project of BioScience.pk
Advertisement

Connect With Us

Contact Us

All comments and suggestions about this web site are very welcome and a valuable source of information for us. Thanks!

Tel: +(92) 302 970 8985-6

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Website: https://www.bioscience.pk



This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.

Our Sponsors

InsightGadgets.comPathLabStudyTheMedicalLibrary.orgThe Physio ClubB2BPakistan.com

By using BioScience.pk you agree to our use of cookies to enhance your experience on this website.