Glossary

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Articulation

Also known as: Joint


Point where two or more bones meet in the body; they allow the body to be flexible and are classified by their range of movement: immovable (fibrous) do not move, such as in the skull, slightly movable (cartilaginous) as in the vertebrae in the spine, or freely movable (synovial) as in the knees and elbows, which move in many directions and are further classified as hinge, pivot or ball-and-socket joints.

Digital Rectal Exam

Also known as: DRE

Part of a physical examination performed in order to examine nearby structures (e.g., the prostate in men)

ECG, EKG

Also known as: ElectrocarDiogram

Graphic recording of the electrical activity of the heart

Granulocyte

Also known as: Neutrophil


Normally the most abundant type of white blood cell in healthy adults

Microbe

Also known as: Microorganism

Life form that is not visible to the naked eye such as bacteria, fungi, parasites, and viruses

24-Hour Urine Sample

A collection of all urine voided over a 24-hour period of time.

Obtain a collection container from your doctor or the laboratory and follow the directions you are given for collecting your samples. To preserve the substance to be tested, the container may need to be refrigerated during the entire collection process. After getting up in the morning, empty your bladder and discard that urine. Note the time. For the next 24 hours, save all urine voided in the container provided. When 24 hours are over, empty your bladder and ADD this urine to the container. Note the time. Bring all of the urine collected to the lab or doctor's office. If you miss collecting one or more voids, consult your doctor or the laboratory for further instructions.

The reason a 24-hour urine sample may be requested instead of a random urine sample is because amounts of various substances in the urine changes during the course of a day. By collecting all urine for 24 hours, the amount of the substance being measured in the urine can be averaged over the entire day and will give a better indication of what is going on in the body.

Abnormal Fibrinolysis

Overactivity of the process normally responsible for clearing blood clots from blood vessels

ABO Incompatibility
ABO incompatibility is a common and generally mild type of haemolytic disease in babies. The term haemolytic disease means that red blood cells are broken down more quickly than usual which can cause jaundice anaemia and in very severe cases can cause death. During pregnancy this breakdown of red blood cells in the baby may occur if the mother and baby’s blood types are incompatible and if these different blood types come into direct contact with each other and antibodies are formed.
Abscess

An enclosed localized collection of pus formed by the disintegration of tissue within a cavity

Acanthosis nigricans

Darkening and thickening of the skin around the neck, underarms, and skin folds; can be caused by elevated levels of insulin in the blood and is often associated with obesity

Acid

A compound that contains at least one hydrogen atom and can react with a base to form a salt; a chemical with a pH less than 7. An example of acid in the body is hydrochloric acid (HCl) involved in digestion in the stomach.

Acid-Base Balance

The body's maintenance of a healthy pH range for blood and tissues that is slightly basic (pH between 7.35 - 7.45). This balance is achieved through the use of systems in the blood (which help to minimize pH changes) and by the lungs and kidneys, which eliminate excess amounts of acids or bases from the body.

Acidosis

A condition in which there is a shift in the acid-base balance of the body to have more acid than normal, often causing the pH of the blood and body tissues to fall below the healthy range (7.35-7.45). It may be caused by decreased CO2 eliimination in respiratory disorders such as emphysema, by metabolic problems such as kidney disease and diabetes, or as the result of ingesting poisons (ethlylene glycol, methanol) or overdosing on certain medication (salicylates); it can also be caused by losing HCO3, as in diarrhea.

Acromegaly

A condition in adults resulting from excess growth hormone characterized by enlargement of the hands and feet, change in shoe size, gradual changes in facial features, including protrusion of the lower jaw and brow, and enlargement of the nasal bone

Acute coronary syndrome

Also known as: ACS


A group of potentially life-threatening disorders resulting from insufficient blood flow to the heart caused by the narrowing or blockage of one or more blood vessels to the heart; the conditions included in this group range from unstable angina to heart attack and are usually characterized by chest pain, upper body discomfort with pain in one or both arms, shoulders, stomach or jaw, shortness of breath, nausea, sweating or dizziness.

Acute Myelocytic Leukemia

Also known as: Acute Myelocytic Leukemia, AML


bone marrow disease that is characterized by the production of large numbers of an immature granulocyte (a neutrophil -- the most common, basophil, or eosinophil) that replace other normal cells in the marrow.

Acute Myelocytic Leukemia, AML

Also known as: Acute Myelocytic Leukemia, AML


bone marrow disease that is characterized by the production of large numbers of an immature granulocyte (a neutrophil -- the most common, basophil, or eosinophil) that replace other normal cells in the marrow.

Acute Phase Reactant

A protein that increases or decreases in concentration with conditions that cause acute tissue inflammation or trauma.

Acute Sample

In the clinical laboratory, pertaining to samples taken at a time when a patient initially exhibits signs and symptoms of a disease or condition

Adenomatous polyp

Also known as: Tubular adenoma


Abnormal growth of cells that form the glands in the lining of the colon or rectum; while benign, may become cancerous over time

Adjuvant therapy

Treatment used to assist a primary therapy (such as surgery) in the prevention, improvement, or cure of a disease (such as adjuvant chemotherapy in cancer)

Adrenal Gland

Also known as: Suprarenal gland


One of a pair of glands located above each kidney that secretes hormones directly into the bloodstream. Each gland has two parts that perform different functions.
1. The adrenal cortex produces and secretes hormones such as cortisol, aldosterone and sex steroids. They are involved in many different body functions.
2. The adrenal medulla produces and secretes catecholamines such as adrenaline (epinephrine) and norepinephrine.

Aerobic

Living or occurring in an oxygen-rich environment

Afibrinogenemia

The absence of fibrinogen production

Alkalosis

A condition in which a there is a shift in the acid-base balance of the body to have more base than normal, often causing the pH of the blood and body tissues to rise above the healthy range (7.35-7.45). It may have respiratory causes such as hyperventilation and pneumonia or metabolic causes such as prolonged vomiting and severe dehydration.

Allele

Any one of the possible alternative forms in which a specific gene can occur

Allergen

Substance (e.g., ragweed pollen) that can cause an allergy

Alopecia
Ambiguous genitalia

Sex organs (genitals) that are not distinctly male or female in appearance. It is a condition present at birth (congenital) that results from a disruption in the formation of sex organs during fetal development.

Amenorrhea
Amino Acid

One of a group of chemical compounds (organic acids) that have an amino group (NH2); many are the building blocks of proteins.

Amniotic fluid

Fluid surrounding and supporting a fetus

Amplification

1) In molecular diagnostics, a process by which multiple copies of genetic material (RNA, DNA) are generated so as to produce adequate levels of the target to be detected or quantitated

2) The process by which the signal from a detection system is increased so as to improve detection or quantitation of an analyte of interest, such as genes or drugs

3) When there is more than the normal number of copies of a gene or genes in a cell, as in tumor cells, the gene is said to be amplified.

Anaerobic

Living or occurring in an oxygen-free environment

Analyte

Also known as: Test


In the clinical laboratory, a substance from the body that is undergoing analysis.  In lay terms, often referred to as a "test."

Anaphylaxis

Severe allergic reaction that can cause intensely itchy welts (hives) on the skin, low blood pressure, and difficulty breathing. Anaphylaxis can be life-threatening so those who have been affected by it may be advised to carry an emergency injection of epinephrine.

Androgens

Hormones that are responsible for the induction of sexual differentiation and produce secondary male physical characteristics such as a deep voice and facial hair. An example is the hormone testosterone. They are also present in females as precursors to female hormones (such as estrogen).

Anencephaly

Congenital defect that occurs during fetal brain development when the neural tube fails to close properly at the head. The result is the lack of development of a large portion of the brain and skull.

Aneuploidy

Having an abnormal number of chromosomes

Aneurysm

Weakened portion of a blood vessel wall that widens or bulges and may eventually rupture; a ruptured aneurysm can bleed heavily and may be fatal.

Angioedema

Weakened portion of a blood vessel wall that widens or bulges and may eventually rupture; a ruptured aneurysm can bleed heavily and may be fatal.An allergic reaction involving the skin and deeper (subcutaneous) layers that is characterized by patches of swelling

Angioplasty

Medical procedure used to widen blood vessels that have been narrowed or blocked.  During the procedure, a balloon-tipped catheter is inserted into the body (usually through a small incision in the groin). The catheter is guided to the site of the blockage using X-rays and injected dye. The balloon on the catheter is then gently inflated to flatten the blockage and open the blood vessel.

Anovulation

An egg is not released by the ovaries during a menstrual cycle

Anterior

At or toward the front

Antibiotic resistance

Ability of a microorganism to grow despite the presence of an antibiotic

Antibody
Antibodies also called immunoglobulins are large Y-shaped proteins which function to identify and help remove foreign antigens or targets such as viruses and bacteria. Every different antibody recognizes a specific foreign antigen.
Antibody

Also Known As: Ig; Antibody; Immune serum globulin; Immune globulin; Gamma globulin



1) Special proteins produced by the body in response to foreign substances including bacteria and viruses; there are five structurally distinct classes of immunoglobulins produced by plasma cells in the bone marrow and other lymphoid tissue that bind to and neutralize foreign substances (antigens). The five major kinds of immunoglobulins are A, D, E, G and M.

2) A solution made from human blood plasma that contains concentrated antibodies that protect against specific diseases, such as short-term protection against certain infections and Rh sensitization during pregnancy; it is made from human blood plasma that has been pooled, processed from donated blood, and purified.

Anticoagulant

1. Drug that delays blood clotting (e.g., heparin, warfarin); used in patients with or at risk for blood clots
2. Substance used to prevent clotting in blood used for transfusions and certain laboratory tests

Antigen

1. Substance that causes the production of an antibody that binds to the antigen in order to damage, neutralize or kill it.
2. The presence of certain antigens on blood cells is the basis for blood typing for transfusions. Antigens that are present on tissue allow for donor-recipient matching in transplant medicine.

Antigen Testing

Also known as: Quantity Testing


Quantity testing measures how much of a particular substance or analyte is present. This type of testing can measure amounts of coagulation factors, hormones, enzymes, and many other substances. It does not, however, evaluate how well the substance is working or performing its role in the body.

Antihistamine

A class of drugs that is used to treat allergies, hypersensitivity reactions, and the symptoms of colds. These drugs work by reducing the effects of histamine, a naturally-occurring substance that is released in response to inflammation and allergies.

Apheresis

Process of removing a specific component from blood, such as platelets or white blood cells, and returning the remaining components to the donor; allows for more of one particular component to be collected than could be separated from a unit of whole blood

Apnea

Short pauses or cessations in breathing

Apoprotein

General term for a protein without its characteristic prosthetic group, which may be a metal or a small organic compound; for example, the protein apotransferrin combines with iron to form transferrin, and protein apoceruloplasmin combines with copper to form the enzyme ceruloplasmin.

Arrhythmia

Changes in the rhythm of heartbeats or in the strength of heart contractions

Ascites

Fluid buildup in the peritoneal (abdominal) cavity

Aspiration

Use of suction to take liquids, gases, or cells from a body cavity or area, as in aspiration biopsy

Assay

Procedure used to detect or measure a substance or reaction; test

Asymptomatic

Without symptoms.

Atherosclerosis

Common disorder of the arteries in which deposits consisting mostly of cholesterol and lipids form on the inner arterial wall. As a result, the vessels become nonelastic and narrowed, leading to decreased blood flow. One of the most important examples is coronary artery disease.

Atrial Fibrillation

Condition characterized by an irregular, often rapid, heart rhythm

Auer Bodies

Also known as: Auer Rods

unique, pink or red rod-shaped inclusions that are seen in very immature granulocytes ("blasts") in people with acute non-lymphocytic leukemia (i.e., acute myeloid leukemia; AML)

Auer Rods

Also known as: Auer Bodies

unique, pink or red rod-shaped inclusions that are seen in very immature granulocytes ("blasts") in people with acute non-lymphocytic leukemia (i.e., acute myeloid leukemia; AML)

Autoimmunity

Misdirected immunity with production of antibodies that act against the tissues of one's own body

Bacteremia

Presence of bacteria in the blood

Bacterium

Plural: Bacteria
Unicellular microscopic organisms, some of which cause disease

Base

1) Substance that has a hydroxyl (OH) ion, tastes bitter, has a pH greater than 7 and, when combined with an acid, forms a salt; example of a base is ammonia
2) One of the building blocks of DNA and RNA

Basophil

Type of white blood cell (leukocyte), with coarse granules that stain blue when exposed to a basic dye. Basophils normally constitute 1% or less of the total white blood cell count but may increase or decrease in certain diseases.

Benign

1. Mild, non-cancerous, and/or not spreading (compare Malignant), as of a disease or growth, esp. a benign tumor.
2. Associated with disease or condition that has mild or minimal consequences for the patient.

Beta Blockers

Beta Blockers

A group of drugs that blocks the effect of adrenaline, slows the heart rate, and decreases the strength of the heart's contractions and thereby lowers blood pressure and relieves symptoms of angina and arrhythmias

Beta Cells

Specialized cells in the pancreas that produce and secrete insulin

Bile

Thick, yellow-green-brown fluid made by the liver, stored in the gallbladder, and discharged into the upper part of the digestive tract (duodenum), where it dissolves fats, preparing them for further digestion.

Biliary

Pertaining to bile or the ducts of the liver and gall blader

Biomarker

A substance produced by the body, often detectable in body fluids such as blood or urine, that indicates a specific process, condition or disease

Biopsy

Removal of a small amount of tissue and/or fluid; the specimen is usually obtained by cutting or by suction through a needle.

Bite cells

Abnormally-shaped red blood cells with one or more semicircular portions removed from the cell margin, appearing as though the cells have had "bite" or "bites." The "bites" result from the removal of hemoglobin with an altered structure (denatured) by special cells (macrophages) in the spleen. G6PD deficiency is a common disorder that leads to the formation of bite cells, which can be seen in a stained blood smear.

Blast

Immature or primitive cell; precursor cell

Blepharoplast

A basal body especially of a flagellated cell.

Blister

Also known as: Vesicle


A small raised area of the outer layer of the skin filled with a watery liquid

Boil

Also known as: Furuncle


A painful, inflamed area of skin with a defined border, collection of pus and a hard central core usually caused by a bacterial infection of a hair follicle and surrounding tissue

Bone Marrow

Specialized soft tissue found within bone. Red bone marrow, widespread in the bones of children and found in some adult bones (e.g., pelvis, spine, ribs), is essential for the formation of mature red blood cells. Fat-laden yellow bone marrow, more common in adults, is found primarily at the ends of long bones.

Breakpoint

In genetics, the particular sites of disruption when chromosomes break (and recombine)

Brittle diabetes

Describes diabetes that is difficult to control, with frequent swings in blood glucose levels between very high and very low

Broad-spectrum Antibiotic Therapy

Treatment with one or more drugs that is effective against a wide variety of bacteria

Bronchiectasis

A condition in which the airways are stretched and/or widened that can be caused by recurrent inflammation or infection of the airways and results in symptoms such as bluish skin, coughing and wheezing, and shortness of breath

Bronchioles

The smaller airway passages/branches of the lower respiratory tract

Bronchiolitis

Also known as: Croup


Inflamed bronchioles, the smaller airway passages/branches of the lower respiratory tract

Bronchus

Also known as: Bronchi (plural)


One of the two main branches of the windpipe (trachea) that lead directly to the lungs

Calcification

Hardening of tissue resulting from the formation of calcium salts

Calibrate

To adjust the output or reading from a testing device to assure that it gives a correct answer; the adjustment is based on measurement of one or more known substances called standards (or calibrators).

Capillary

The tiniest of blood vessels. Through the one-cell-layer-thick walls of capillaries, oxygen and nutrients are delivered to body tissues and carbon dioxide and other wastes are cleared from body tissues.

Carbohydrate

The starches and sugars that are the chief energy sources of the body

Carbuncle

A collection of boils caused by an infection of a large area of skin involving several hair follicles and deeper layers of tissue; the area often has several openings for pus drainage and sloughing dead tissue

Carcinoid tumor

Slow-growing mass that can develop in the mucous membrane of the gastrointestinal (GI) tract and sometimes the lungs

Cardiovascular System

The heart and blood vessels involved in the pumping of blood and the transport of nutrients, oxygen, and waste products throughout the body

Carrier

1. Person, generally in apparent good health, who harbours organisms that can infect and cause disease in others
2. Person who has one copy of a recessive disease gene but is not affected themselves

Cartilage

Tissue that lines joints to absorb shock; it also forms the shape of the nose and ears.

Catheter

1. long, thin, flexible tube inserted into a body cavity or vessel to allow the passage of fluids
2. thin, flexible tube inserted into a vessel in the body for the purpose of opening (distending) the vessel

Central Nervous System

Also known as: CNS

One of the two main divisions of the human nervous system, consisting of the brain and the spinal cord; the other division is the peripheral nervous system.

Centrifugation

The automated process of separating lighter portions of a solution, mixture, or suspension from the heavier portions, by centrifugal force

Cerebrospinal Fluid

Also known as: CSF

Normally clear liquid, produced in the ventricles of the brain, that surrounds the brain and spinal cord

Cervical Adenitis

Lymph node inflammation in the neck

Chain of Custody

Legal document created when a piece of evidence is obtained that records the movement, location, handling and/or testing of the evidence from the time it is collected until the evidence is used in a legal proceeding and/or until it is no longer needed and is discarded or destroyed

Chelation

Binding of a metal ion by a large molecule to form a soluble complex; chelation therapy uses large molecules such as EDTA (ethylene diamine tetraacetic acid) to remove excess metals (like lead or iron) from tissues and enable their excretion.

Chemotherapy

Also known as: Chemo

In the treatment of cancer, the use of medicines or drugs to stop or slow the growth of cancer cells; because chemo can also harm healthy cells, it can be associated with side effects, such as fatigue, hair loss, mouth sores, and nausea/vomiting.

Chloroquine

Drug used in the treatment and prevention of malaria

Chromosome

Threadlike structure in every cell nucleus that carries the inheritance factors (genes) composed of DNA (deoxyribonucleic acid, the gene material) and a protein (usually histone). A human cell normally contains 46 chromosomes, or 22 homologous pairs and 1 pair of sex chromosomes; one member of each pair of chromosomes is derived from each parent.

Chronic

A condition or illness that arises slowly over days or weeks and may or may not resolve with treatment. It is the opposite of acute.

Cirrhosis

Chronic disease condition of the liver in which fibrous tissue and nodules replace normal tissue, interfering with blood flow and normal functions of the organ

Clone

(noun) Cell, group of cells, or organisms that descend from a single cell or organism; clones are genetically identical

(verb) To replicate or produce identical copies

CNS

Also known as: central nervous system

One of the two main divisions of the human nervous system, consisting of the brain and the spinal cord; the other division is the peripheral nervous system.

Cognitive

(n. cognition) Relating to the mental process of acquiring knowledge through awareness, perception, intuition, and reasoning

Collagen

A group of proteins that form elongated fibers that are the main component in connective tissues such as skin, ligaments, tendons, cartilage and bone

Colonization

The presence or growth of bacteria on or in the body; those who are colonized may or may not develop an infection and/or may spread the bacteria to others, in whom they may cause disease.

Colonoscopy

Examination of the rectum and entire colon with a flexible lighted instrument

Colposcopy

a procedure in which a health practitioner uses a lighted magnifying instrument to examine a woman's cervix for abnormal areas, to take samples for biopsy, and/or treat as indicated

Congenital

Present at birth

Conjugated bilirubin

A water-soluble form of bilirubin formed in the liver by the chemical addition of sugar molecules to unconjugated bilirubin; when present in the blood, conjugated bilirubin can become chemically bound to albumin, forming delta-bilirubin (also known as biliprotein).

Connective tissue

Tissue that connects organs or other structures within the body. It supports, attaches and encloses organs, fills the spaces between them, and forms ligaments and tendons.

Convalescent Sample

In the clinical laboratory, pertaining to samples taken at a time when a patient is recovering from a disease or condition

Corpus Luteum

Literally, yellow body in the ovary; the progesterone-producing tissue that remains after an egg is releaed from the ovary

Croup

Also known as: bronchiolitis
Inflamed bronchioles, the smaller airway passages/branches of the lower respiratory tract

Cryoprecipitate

A component prepared from donated blood; after freezing plasma and thawing, a precipitate that remains solid. It is rich in fibrinogen and Factor VIII.

CSF

Also known as: Cerebrospinal Fluid

Normally clear liquid, produced in the ventricles of the brain, that surrounds the brain and spinal cord

Culture

Deliberate growing of cells, especially microorganisms, in a solid or liquid medium (e.g. agar, gelatin), as of bacteria in a Petri dish

Cyst

1) a hollow space or fluid-filled cavity surrounded by a distinct lining that develops abnormally in tissue or in an organ in the body, such as "ovarian cyst"

2) a cellular form of a parasite that has a thick cell wall, which allows for survival of the parasite in the environment and transmission into an uninfected host

Cytokine

one of a group of proteins released by cells of the immune system that carry signals to neighboring cells to regulate and/or promote an immune response

Cytology

The microscopic assessment of individual cells or groups of cells that are either shed in body fluids or collected by smears and scrapings (e.g., the Pap smear) or by aspiration from deeper tissues through a very fine needle

Cytoplasm

The living substance within a cell that is located outside of the nucleus; it is a semi-fluid substance consisting of proteins, fat and other molecules

Dehydration

Excessive loss of water from the body tissues, often accompanied by imbalance of sodium, potassium, chloride, and other electrolytes

Dementia

Progressive state of mental decline, especially of memory function and judgment

Dermatitis

Acute or chronic inflammation of the skin

Dermatophyte

Any one of the group of fungi that cause infection of the skin, hair, or nails

Diabetes insipidus

A disorder similar to diabetes mellitus in that it causes symptoms such as increased thirst and increased urine production, but differing in cause, frequency, treatment, and associated complications; diabetes insipidus results from a lack of production of arginine vasopressin (also called antidiuretic hormone or ADH) by the pituitary or a lack of response of the kidneys to ADH, causing an inability of the kidneys to conserve water. It can lead to severe dehydration and high serum sodium if inadequately treated. Diabetes inspididus is a much more rare condition than diabetes mellitus.

Differentiate

Change from an original unspecialized form, to a different more specialized form or function.

Diuretic

Drug that promotes the production and excretion of urine in order to remove excess fluid from the body in, for example, conditions such as congestive heart failure or hypertension

Diverticulosis

A condition characterized by having pouches (diverticulum) that poke through parts of the colon

DNA

Also known as: Deoxyribonucleic acid

The unique genetic code found in all living cells (bacteria, viruses, parasites, plants, and animals).

Dominant gene

One of a pair of genes whose action is expressed even when only one copy is present

Doping

The use of substances or procedures to improve athletic performance and give an athlete an unfair advantage over other competitors.

Double contrast barium enema

Also known as: DCBE

Series of x-rays of the colon and rectum; patient is given an enema with a white, chalky solution that outlines the colon and rectum on the x-rays.

DRE

Also known as: Digital Rectal Exam
Part of a physical examination performed in order to examine nearby structures (e.g., the prostate in men)

Dumping syndrome

Symptoms such as nausea, cramping, sweating, and weakness that may occur when the stomach contents are emptied rapidly into the small intestine before being digested; may occur in patients who have had gastric resections or bypass surgery

Duodenum

first part of the small intestine that receives digesting material from the stomach

Dysfibrinogenemia

The production of abnormal fibrinogen

Dyslipidemia

Unhealthy lipid levels

Dyspnea

Shortness of breath; labored breathing

Dystonia

Persistent muscle contractions that can cause limb twisting and repetitive motions

E. coli

A species of bacteria that normally resides in the gastrointestinal tract as harmless normal flora; these rod-shaped bacteria commonly cause urinary tract infections, and some strains produce toxins that cause diarrheal disease.

Echocardiography

Diagnostic procedure using ultrasound waves to study the heart, its structure and motions; images from this procedure are called echocardiograms.

Eclampsia

Coma and convulsive seizures that occur at or after the 20th week of pregnancy. Associated with pregnancy-induced hypertension, it can be fatal if untreated.

Ectopic Pregnancy

Coma and convulsive seizures that occur at or after the 20th week of pregnancy. Associated with pregnancy-induced hypertension, it can be fatal if untreated.Abnormal pregnancy in which the fertilized egg implants outside of the uterus, most often (90%) in the fallopian tube (tubal pregnancy)

Eczema

Skin condition characterized by red, itchy, scaly and sometimes blistering patches

Edema

Abnormal collection of fluid in spaces between cells, esp. just under the skin or in a given cavity (e.g., peritoneal cavity) or organ (e.g., the lungs-pulmonary edema)

Effusion

Escape of fluid from blood vessels or lymphatic system into a body cavity or space

Electrocardiogram

Also known as: ECG, EKG

Graphic recording of the electrical activity of the heart

Embolism & Thromboembolism

Embolism— a condition in which material (tissue, fat, air, blood clot, etc.—called an embolus) travels through the bloodstream and then becomes lodged in a vein or artery and blocks the flow of blood through that blood vessel.

Thromboembolism—a blood clot (thrombus) that breaks free in the blood stream and blocks a blood vessel. This can occur in a vein (venous thromboembolism) or in an artery (arterial thromboembolism).

Emphysema

Chronic progressive lung disease in which air sacs (alveoli) in the lungs are damaged, resulting in loss of elasticity and function of the lungs; the condition is characterized by shortness of breath and may be accompanied by a cough.  It may eventually lead to heart damage.

Encephalopathy

Any disease causing deterioration of the brain

Endemic

Commonly occurring in a particular population or geographic region

Endocarditis

Inflammation of the membranes lining the interior of the heart and heart valves

Endocrine

Cells or tissue that produce hormones released into the bloodstream that have an affect on other cells; for example, the thyroid gland produces thyroid hormone that affects metabolism of many cells.

Endogenous

Originating in or produced within an organ, tissue, cell or by the body. The term may be used to distinguish between an internal or external source of a substance, such as insulin or testosterone.

Endometriosis
 
Enzyme

Protein produced in cells that speeds up the rate of biological reactions; the names of many enzymes end in "-ase" (e.g., lipase, amylase).

Eosinophil

Leukocyte (white blood cell) with granules that are stained by the dye, eosin. Eosinophils, normally about 1-3% of the total white blood cell count, are believed to function in allergic responses and in resisting some infections.

Epidemic

Outbreak of an infectious disease that spreads rapidly among a population in a defined geographic area

Erectile dysfunction

Repeated inability to achieve or sustain an erection

Exchange Transfusion

Removal of some of a person's blood and its replacement with equal amounts of donor blood

Exocrine

Cells or tissue that produce substances that are released through a duct and into another organ; for example, the pancreas releases digestive juices into the intestine.

Exogenous

External, originating outside of an organ, tissue, cell or the body. It may refer to a substance that is administered to the body, such as exogenous insulin or testosterone.

Exudate

Fluid that has leaked into a body cavity as a result of injury or inflammation; it has a higher than normal protein content and may be cloudy due to increased numbers of white blood cells.

False-Negative

Test or procedure result inappropriately indicating a normal or negative result when, in fact, an abnormal condition is actually present.

False-Positive

Test or procedure result inappropriately indicating a positive or abnormal result when, in fact, no abnormal condition is actually present.

Febrile

Characterized by fever; feverish

Feedback System

Also known as: Feedback Mechanism, Feedback Loop


The body uses feedback systems to control certain functions. A feedback system uses one of the products of a pathway, usually the end product, to control the activity of the pathway and to regulate the amount of that product. Feedback control may be positive or negative.

To understand negative feedback, think of how the thermostat in your house controls the temperature. Lets say that the thermostat is set at 70 degrees F (the end product concentration). When the temperature falls below 70 degrees F, the feedback system is triggered and the furnace lights and starts to pump warm air into the house. When the air in the house reaches 70 degrees F, the thermostat shuts off the furnace (no more product made; no more hot air generated). A negative feedback system maintains a steady state or equilibrium and is the one most commonly found in the body.

Positive feedback systems increase the rate of formation of the product. This tends to cause change in the system rather than maintain a steady state. Think of how when a person works hard and is praised for their efforts (given positive feedback), they work harder still, expecting more praise. There are very few positive feedback systems in the body. One example, however, is lactation. The suckling action of an infant produces prolactin, which leads to milk production; more suckling leads to more prolactin, which in turn leads to more lactation. This is a positive feedback system as the product (milk) produces more suckling and more hormone. When the child is no longer breast feeding, the prolactin drops off and milk production goes down.

Feedback System

Also known as: Feedback Mechanism, Feedback Loop


The body uses feedback systems to control certain functions. A feedback system uses one of the products of a pathway, usually the end product, to control the activity of the pathway and to regulate the amount of that product. Feedback control may be positive or negative.

To understand negative feedback, think of how the thermostat in your house controls the temperature. Lets say that the thermostat is set at 70 degrees F (the end product concentration). When the temperature falls below 70 degrees F, the feedback system is triggered and the furnace lights and starts to pump warm air into the house. When the air in the house reaches 70 degrees F, the thermostat shuts off the furnace (no more product made; no more hot air generated). A negative feedback system maintains a steady state or equilibrium and is the one most commonly found in the body.

Positive feedback systems increase the rate of formation of the product. This tends to cause change in the system rather than maintain a steady state. Think of how when a person works hard and is praised for their efforts (given positive feedback), they work harder still, expecting more praise. There are very few positive feedback systems in the body. One example, however, is lactation. The suckling action of an infant produces prolactin, which leads to milk production; more suckling leads to more prolactin, which in turn leads to more lactation. This is a positive feedback system as the product (milk) produces more suckling and more hormone. When the child is no longer breast feeding, the prolactin drops off and milk production goes down.

Fibroid

Incorrect but commonly used name for leiomyoma, a frequent benign smooth muscle tumor of the uterus

Fibrosis

Abnormal formation of tissue that is tough, sinewy, resembling fibers

Fluorescent Microscope
A fluorescence microscope is an optical microscope that uses fluorescence and phosphorescence instead of or in addition to reflection and absorption to study properties of organic or inorganic substances. The 'fluorescence microscope' refers to any microscope that uses fluorescence to generate an image whether it is a more simple set up like an epifluorescence microscope or a more complicated design such as a confocal microscope which uses optical sectioning to get better resolution of the fluorescent image.
Folliculitis

Infected hair follicles

Fragile X Syndrome

The most common inherited cause of mental retardation; takes its name from the appearance of the stained X chromosome under a microscope – there is a site near the end of this chromosome that does not stain, indicating its fragility. The gene in the fragile region is important in making a special protein needed by developing brain cells.

Functional Testing

Also known as: Activity testing


Functional testing is used to determine whether or not a specific substance is properly performing its biological role in the body and to what extent. This testing can determine how well a specific coagulation factor is performing its role in the coagulation cascade; for example, normal amounts of fibrinogen can be present, but if not working properly, abnormal coagulation results. Functional testing can also determine the correct level of activity of other substances such as hormones and enzymes.

Fungus

Plural: Fungi


One of the four major groups of microorganisms (bacteria, viruses, parasites and fungi) that occurs in nature as a yeast (small unicellular structure similar to bacteria) or a mold (large filamentous forms that may be seen with the naked eye)

Furuncle

Also known as: Boil


A painful, inflamed area of skin with a defined border, collection of pus and a hard central core usually caused by a bacterial infection of a hair follicle and surrounding tissue

Galactorrhea

Breast milk production that occurs without pregnancy

Ganglioside

Type of substance found on the surface of cells, particularly in the brain, that is important in cell-to-cell communication

Gene

Basic unit of genetic material; in humans, a segment of DNA on a chromosome that usually codes for the production of a specific protein

Gene expression

Properties exhibited by an organism due to genes present in cells

Gene Sequence

Section of genetic code; particular arrangement of nucleotides along a segment of DNA on a chromosome

Genetic Counseling

Process of determining the risk of a particular genetic disorder occurring within a family and providing information and advice based on that determination

Genome
The haploid set of chromosomes in a gamete or microorganism or in each cell of a multicellular organism.
  • the complete set of genes or genetic material present in a cell or organism.
Genome

The total of a person's genetic information

Genotype

Specific combination of genes within a cell or cells

Germ cell

Reproductive cell that develops into a sperm in males and an egg in females; germ cells contain one-half of the normal complement of the 46 chromosomes from each parent.

Gestation

Period of development of a fetus between the time an egg is fertilized and birth

Gigantism

A condition in children resulting from excess growth hormone characterized by an abnormal growth of the long bones and increased size of feet and hands

Globulin

Collective term for most blood proteins other than albumin

Glomerulus

Plural: glomeruli; one of a number of specialized structures in the kidney, composed of loops of specialized capillaries that filter blood, allowing small substances to pass through towards the urine but preventing loss of larger proteins and blood cells.

Glycogen

The principal storage form of glucose found primarily in the liver and the muscles.

Goiter

An enlarged thyroid gland

Granuloma

Special form of chronic inflammation; often forms one or more nodules that can involve the skin, lymph nodes, lung, liver, spleen, or other organs. Granulomas often form in response to certain types of infection (especially to mycobacteria such as in tuberculosis and to fungi) or to foreign bodies, but sometimes have no known cause, as in sarcoidosis.

Gynecomastia

Enlargement of breast tissue in the male

Half-life

The amount of time it takes for the body to inactivate or metabolize half of a substance; a second half-life would decrease the remainder by half again, and so on.

Heinz Bodies

Precipitated hemoglobin that can be seen inside red blood cells under the microscope

Hemodialysis

A disorder similar to diabetes mellitus in that it causes symptoms such as increased thirst and increased urine production, but differing in cause, frequency, treatment, and associated complications; diabetes insipidus results from a lack of production of arginine vasopressin (also called antidiuretic hormone or ADH) by the pituitary or a lack of response of the kidneys to ADH, causing an inability of the kidneys to conserve water. It can lead to severe dehydration and high serum sodium if inadequately treated. Diabetes inspididus is a much more rare condition than diabetes mellitus.Also known as: Dialysis
A procedure that removes waste substances from the circulating blood; often performed on patients with kidney disease

Hemodialysis

Also known as: Dialysis
A procedure that removes waste substances from the circulating blood; often performed on patients with kidney disease

Hemoglobinopathy

A group of single gene disorders including structural hemoglobin variants (e.g., sickle cell hemoglobin) and the thalassemias

Hemolysis

Process by which red blood cells disintegrate, releasing their contents

Hemolytic Disease of the Newborn

A condition in which antibodies in a pregnant woman's blood cross the placenta and destroy her baby's red blood cells; develops when the mother and baby have differences in one or more blood group antigens

Hemolytic Uremic Syndrome

Also known as: HUS

A life-threatening condition that may result from the breakdown (hemolysis) of a large number of red blood cells (RBCs) and damage to the kidneys (uremia). Most often it presents as a complication of an infection of the digestive tract caused by certain bacteria that produce a toxin that enters the bloodstream and destroys RBCs. This syndrome is most commonly associated with infections caused by shiga toxin-producing Eschericha coli (STEC), but may also result from infections caused by Salmonella and Shigella, other types of infections, and sometimes from non-infectious causes.

Hemolytic Uremic Syndrome

Also known as: HUS

A life-threatening condition that may result from the breakdown (hemolysis) of a large number of red blood cells (RBCs) and damage to the kidneys (uremia). Most often it presents as a complication of an infection of the digestive tract caused by certain bacteria that produce a toxin that enters the bloodstream and destroys RBCs. This syndrome is most commonly associated with infections caused by shiga toxin-producing Eschericha coli (STEC), but may also result from infections caused by Salmonella and Shigella, other types of infections, and sometimes from non-infectious causes.

Hemorrhage

1. bleeding; escape of blood, usually from injured blood vessels
2. excessive bleeding over a short period of time, either internally or externally; if uncontrolled, can lead to shock and death.

Hemorrhoid

Swelling of vein(s) in the lower part of the rectum or anus

Hemosiderosis

Abnormal deposition of an iron-containing compound (hemosiderin) in tissues, often associated with diseases in which there is extensive destruction of red blood cells (e.g., thalassemia)

Hemostasis

The stopping of bleeding or the flow of blood

Hepatocellular carcinoma

Also known as: HCC

Cancer that originates in the cells of the liver; this type of cancer may develop in those who have certain forms of cirrhosis or who have had a hepatitis B or hepatitis C infection; may develop years after initial infection.

Hepatocellular carcinoma

Also known as: HCC

Cancer that originates in the cells of the liver; this type of cancer may develop in those who have certain forms of cirrhosis or who have had a hepatitis B or hepatitis C infection; may develop years after initial infection.

Hereditary

Genetic; passed from parent to offspring

Heterophile Antibody

A human antibody that reacts with proteins from another species; may lead to innaccurate results in immunoassay tests; sometimes used to refer to antibodies associated with infectious mononucleosis

Heterozygous

Having two different copies of a particular gene, one of which may be abnormal

Hirsutism

Abnormal hairiness, especially an adult male pattern of hair distribution in a female

Human leukocyte antigens

Also known as: HLA


Group of proteins present on the surface of white blood cells (leukocytes) and other nucleated cells (containing a nucleus). These proteins help the body’s immune system to identify its own cells and to distinguish between “self” and “nonself.” Each person has an inherited combination of HLA antigens and, while not as unique as a fingerprint, the presence or absence of each antigen creates a distinctive HLA combination for each person. HLA antigens are divided into types: Class I (A, B, C) and Class II (DR, DP, DQ).

Hydrocephalus

A condition in which the chambers (ventricles) within the brain become enlarged due to an abnormal accumulation of cerebrospinal fluid

Hydropic

Retaining excessive amounts of fluids

Hypercalcemia

Higher than normal calcium level in the blood

Hyperglycemia

Higher than normal glucose levels in the blood

Hyperinsulinemia

Elevated levels of insulin in the blood

Hyperkalemia

Higher than normal potassium levels in the blood

Hyperlipidemia

Higher than normal cholesterol and/or triglyceride levels in the blood

Hyperlipoproteinemia

Higher than normal lipoprotein levels in the blood

Hypernatremia

Higher than normal sodium levels in the blood

Hyperparathyroidism

A condition characterized by an overproduction of parathyroid hormone (PTH), a hormone that controls calcium and phosphate levels in blood and calcium in bone; it is made by the parathyroid glands. Primary hyperparathyroidism causes high calcium and low phosphate levels, and can cause kidney stones occasionally. Secondary hyperparathyroidism is caused by low levels of calcium or vitamin D, or high levels of phosphate; it is commonly caused by chronic kidney disease. Either form can cause osteoporosis or bone pain.

Hyperpituitarism

Condition caused by increased production of pituitary hormones

Hyperplasia

An increase in the number of cells in an organ, causing enlargement of that organ; this term most often refers to glandular organs, such as the prostate and the adrenal glands. Hyperplasia can produce problems related to a gland's larger size (as in benign prostatic hyperplasia) or excess functioning of the gland (as in adrenal hyperplasia).

Hypocalcemia

Lower than normal calcium level in the blood

Hypochromic

Paler than normal red blood cells

Hypofibrinogenemia

Low production of fibrinogen

Hypoglycemia

Lower than normal glucose levels in the blood

Hypogonadism

A condition associated with defective function of the gonads (ovaries in females, testes in males) resulting in little or no production of hormones

Hypokalemia

Lower than normal potassium levels in the blood

Hyponatremia

Lower than normal potassium levels in the blood

Hypoparathyroidism

A condition characterized by underactivity of the parathyroid glands and reduced production of parathyroid hormone (PTH), a hormone that controls calcium and phosphate levels in blood and calcium in bone. Symptoms may include tingling in the fingers and toes, muscle aches and spasms, fatigue, dry skin and brittle nails, headaches, anxiety, and depression.

Hypopituitarism

Condition caused by a decrease in or loss of production of pituitary hormones

Hypopituitarism

Condition caused by a decrease in or loss of production of pituitary hormones

Hypothalamus

Area of the brain located just above the brainstem that controls the pituitary gland and regulates many bodily functions, such as body temperature, hunger, thirst, sleep, and mood through the release of hormones

Hypoxia

Lack of oxygen

Idiopathic

 A disease or condition that does not have an identifiable cause

Ig

Also known as: Ig; Antibody; Immune serum globulin; Immune globulin; Gamma globulin

1) Special proteins produced by the body in response to foreign substances including bacteria and viruses; there are five structurally distinct classes of immunoglobulins produced by plasma cells in the bone marrow and other lymphoid tissue that bind to and neutralize foreign substances (antigens). The five major kinds of immunoglobulins are A, D, E, G and M.

2) A solution made from human blood plasma that contains concentrated antibodies that protect against specific diseases, such as short-term protection against certain infections and Rh sensitization during pregnancy; it is made from human blood plasma that has been pooled, processed from donated blood, and purified.

Immune serum globulin

Also known as: Ig; Antibody; Immune serum globulin; Immune globulin; Gamma globulin

1) Special proteins produced by the body in response to foreign substances including bacteria and viruses; there are five structurally distinct classes of immunoglobulins produced by plasma cells in the bone marrow and other lymphoid tissue that bind to and neutralize foreign substances (antigens). The five major kinds of immunoglobulins are A, D, E, G and M.

2) A solution made from human blood plasma that contains concentrated antibodies that protect against specific diseases, such as short-term protection against certain infections and Rh sensitization during pregnancy; it is made from human blood plasma that has been pooled, processed from donated blood, and purified.

Immune System

The body's means of protection against microorganisms and other foreign substances; it is composed of two major parts: the humoral response (B lymphocytes and production of antibodies) and the cell-mediated response (T lymphocytes that attack foreign substances directly).

immune-suppressed

Also known as: Immune-compromised; immunosuppressed; immune-suppressed

Reduced ability of one's immune system to mount a normal response to infection

Immunity

1) Resistance to infection because of previous exposure to an infectious agent, naturally or by vaccination
2) State of activation of the immune system to recognize a foreign substance

Immunocompromised

Also known as: Immune-compromised; immunosuppressed; immune-suppressed

Reduced ability of one's immune system to mount a normal response to infection

Immunocompromised

Also known as: Immune-compromised; immunosuppressed; immune-suppressed

Reduced ability of one's immune system to mount a normal response to infection

Immunocompromised

Also known as: Immune-compromised; immunosuppressed; immune-suppressed

Reduced ability of one's immune system to mount a normal response to infection

Immunoglobulin A

Also known as: IgA


One of the five classes of immunoglobulins; one of the most common immunoglobulins, it is mainly present in body secretions and is the chief antibody in the mucous membranes of the gastrointestinal and respiratory tract and in saliva and tears.

Immunoglobulin A

Also known as: IgA


One of the five classes of immunoglobulins; one of the most common immunoglobulins, it is mainly present in body secretions and is the chief antibody in the mucous membranes of the gastrointestinal and respiratory tract and in saliva and tears.

Immunoglobulin D

Also known as: IgD


One of the five classes of immunoglobulins; it is present in small amounts in serum and is thought to function in certain allergic responses

Immunoglobulin D

Also known as: IgD


One of the five classes of immunoglobulins; it is present in small amounts in serum and is thought to function in certain allergic responses

Immunoglobulin E

Also known as: IgE


One of the five classes of immunoglobulins; it is present primarily in the skin and mucous membranes and is believed to function in response to environmental antigens and to play a role in allergic reactions.

Immunoglobulin E

Also known as: IgE


One of the five classes of immunoglobulins; it is present primarily in the skin and mucous membranes and is believed to function in response to environmental antigens and to play a role in allergic reactions.

Immunoglobulin G

Also known as: IgG


One of the five classes of immunoglobulins; widespread in the body, it provides long-lasting defense against most bacterial invasions and other antigens.

Immunoglobulin G

Also known as: IgG


One of the five classes of immunoglobulins; widespread in the body, it provides long-lasting defense against most bacterial invasions and other antigens.

Immunoglobulin M

Also known as: IgM


One of the five classes of immunoglobulins; a large molecule, it is found in blood and is involved in combating blood infections. It is the first or primary immunoglobulin produced following exposure to an antigen.

Immunoglobulin M

Also known as: IgM


One of the five classes of immunoglobulins; a large molecule, it is found in blood and is involved in combating blood infections. It is the first or primary immunoglobulin produced following exposure to an antigen.

Immunoglobulins

Also known as: Ig; Antibody; Immune serum globulin; Immune globulin; Gamma globulin


1) Special proteins produced by the body in response to foreign substances including bacteria and viruses; there are five structurally distinct classes of immunoglobulins produced by plasma cells in the bone marrow and other lymphoid tissue that bind to and neutralize foreign substances (antigens). The five major kinds of immunoglobulins are A, D, E, G and M.

2) A solution made from human blood plasma that contains concentrated antibodies that protect against specific diseases, such as short-term protection against certain infections and Rh sensitization during pregnancy; it is made from human blood plasma that has been pooled, processed from donated blood, and purified.

Immunoglobulins

Also known as: Ig; Antibody; Immune serum globulin; Immune globulin; Gamma globulin

1) Special proteins produced by the body in response to foreign substances including bacteria and viruses; there are five structurally distinct classes of immunoglobulins produced by plasma cells in the bone marrow and other lymphoid tissue that bind to and neutralize foreign substances (antigens). The five major kinds of immunoglobulins are A, D, E, G and M.

2) A solution made from human blood plasma that contains concentrated antibodies that protect against specific diseases, such as short-term protection against certain infections and Rh sensitization during pregnancy; it is made from human blood plasma that has been pooled, processed from donated blood, and purified.

Immunoglobulins

Also known as: Ig; Antibody; Immune serum globulin; Immune globulin; Gamma globulin

1) Special proteins produced by the body in response to foreign substances including bacteria and viruses; there are five structurally distinct classes of immunoglobulins produced by plasma cells in the bone marrow and other lymphoid tissue that bind to and neutralize foreign substances (antigens). The five major kinds of immunoglobulins are A, D, E, G and M.

2) A solution made from human blood plasma that contains concentrated antibodies that protect against specific diseases, such as short-term protection against certain infections and Rh sensitization during pregnancy; it is made from human blood plasma that has been pooled, processed from donated blood, and purified.

Immunoglobulins

Also known as: Ig; Antibody; Immune serum globulin; Immune globulin; Gamma globulin

1) Special proteins produced by the body in response to foreign substances including bacteria and viruses; there are five structurally distinct classes of immunoglobulins produced by plasma cells in the bone marrow and other lymphoid tissue that bind to and neutralize foreign substances (antigens). The five major kinds of immunoglobulins are A, D, E, G and M.

2) A solution made from human blood plasma that contains concentrated antibodies that protect against specific diseases, such as short-term protection against certain infections and Rh sensitization during pregnancy; it is made from human blood plasma that has been pooled, processed from donated blood, and purified.

Immunosuppressive

Pertaining to a substance that decreases the body's normal immune response

Impetigo

Shallow, fluid-filled blisters surrounded by yellow crusts

in situ

 1. confined to the original site

2. in the original position

In utero

Within the uterus

In vitro

Outside the body; in the clinical lab, in an artificial environment such as a test tube or petri dish

In vivo

Within the body; within a living environment

Incidence

Rate at which new cases of a disease occur within a population

Incubation period

Time between exposure to an infectious agent, such as a virus, and the onset of symptoms of disease

Infarction

Tissue death caused by the blockage of blood flow by a blood clot or other material

Infection

Disease caused by microorganisms

Inflammation

The response of body tissues to injury such as trauma or infection. Inflammation is a complex process that can be localized or systemic. When localized, it causes pain, heat, swelling and redness of the affected area; when systemic, it may present as a general feeling of malaise with fatigue and fever.

Inhibitor

1) A substance that stops, blocks, or slows down the action of an enzyme
2) A substance that stops or impedes a process from taking place in the body

Insulinoma

A tumor of the insulin-producing islet cells in the pancreas, causing low blood glucose levels

Intramuscular

Within a muscle, as an injection

Intravenous

Into or within a vein

Iron Deficiency Anemia
Anemia occurs when you have a level of red blood cells (RBCs) in your blood that is lower than normal. Iron deficiency anemia is the most common type of anemia and it occurs when your body doesn't have enough of the mineral iron. Your body needs iron to make a protein called hemoglobin.
Iron-Deficiency Anemia
Anemia occurs when you have a level of red blood cells (RBCs) in your blood that is lower than normal. Iron deficiency anemia is the most common type of anemia and it occurs when your body doesn't have enough of the mineral iron. Your body needs iron to make a protein called hemoglobin.
Ischemia

Decreased supply of blood and therefore oxygen to tissue, organ (heart, brain) or body part often caused by a blockage or constriction of blood vessels

Islet cells

Specialized cells in the pancreas that produce and secrete one of several hormones that affect certain body functions; some examples include alpha cells that produce glucagon and beta cells that produce insulin.

Joint

Also known as: Articulation


Point where two or more bones meet in the body; they allow the body to be flexible and are classified by their range of movement: immovable (fibrous) do not move, such as in the skull, slightly movable (cartilaginous) as in the vertebrae in the spine, or freely movable (synovial) as in the knees and elbows, which move in many directions and are further classified as hinge, pivot or ball-and-socket joints.

Keratin

A fibrous protein found in the hair, nails, and outer layer of the skin

Ketoacidosis

Abnormal increase of acid in the blood due to accumulation of substances derived from metabolism of fat (ketone bodies); usually due to severe insulin deficiency in diabetes or to prolonged lack of carbohydrate intake

Ketone bodies

Also known as: Ketones


Byproducts of fat metabolism; may be found in urine or blood if a person does not eat enough carbohydrates or if the persons body cannot use them properly, such as with diabetes mellitus

Ketones

Also known as: Ketone bodies


Byproducts of fat metabolism; may be found in urine or blood if a person does not eat enough carbohydrates or if the persons body cannot use them properly, such as with diabetes mellitus

Klinefelter syndrome

Also known as: XXY disease

A rare genetic condition in boys and men caused by an extra X chromosome. (Males normally have one X and one Y chromosome.) The presence of the extra X chromosome may or may not produce obvious signs and symptoms (usually in teens and adults), such as low testosterone, small penis and testicles, enlarged breasts, tall stature and/or behavioral, learning, speech or language disabilities. Most of these individuals are infertile.

Latent

Condition or infectious agent that is present in the body but not causing symptoms and/or actively multiplying; the condition may progress from a latent to active form if the immune system of the patient is no longer able to hold the condition or infection in check.

Leukocytosis

 Increase in the number of white blood cells (WBC)

 

Leukopenia

Decrease in the number of white blood cells

Lipemic

Containing high levels of lipids or fats in the blood

Lipids

Any of a group of fats and fat-like substances, including oils, waxes, steroids, and triglycerides. Lipids are easily stored in the body, and triglycerides serve as a fuel source. Some (such as cholesterol and phospholipids) are an important constituent of cell structures and are involved in many biological functions. Lipids can combine with other compounds to form complexes, such as lipoproteins, phospholipids, and glycolipids.

Lipoprotein

Protein in the blood whose primary purpose is to transport cholesterol, tryglycerides, and other fats throughout the body

Lymphatic system

(also Lymph, Lymph tissue, Lymph node)

The extensive network of nodes, vessels, and ducts that collects lymph from tissues and carries it in one direction to the blood. Lymph is clear, watery fluid consisting of a number of substances including fat, protein and lymphocytes, the white blood cells that fight infections. Lymph and the lymphatic system serve to transport these substances, remove fluid and bacteria from tissues, and supply mature lymphocytes to the blood.

Lymphocyte

Leukocyte (white blood cell) that normally makes up about 25% of the total white blood cell count but can vary widely. Lymphocytes occur in two forms: B cells, which produce antibodies, and T cells, which recognize foreign substances and process them for removal.

Macrophage

A large white blood cell (WBC) found in connective tissue, lymph nodes, spleen, bone marrow and other tissues; it is an important part of the body's immune system and helps fight infections by surrounding and ingesting disease-causing microorganisms.

Malignant

Harmful and potentially fatal

Mammogram

Examination of the breast by X-ray

Mast cell

A type of tissue cell found throughout the body but especially in connective tissue such as the skin, lining of the intestine and air passages as well as in the bone marrow. Mast cells contain granules that store chemicals. These chemicals are released as part of the body's normal response to injury but also may be released as part of an allergic response to exposure to an allergen. The chemicals that are released can cause the allergic signs and symptoms.

Mastocytosis

Abnormal accumulation of mast cells within one or more organs. Mast cells are a type of tissue cell found throughout the body that release chemicals as part of the body's normal response to injury but sometimes as part of an allergic response. Cutaneous mastocytosis is a benign disease of the skin, usually affecting children. Systemic mastocytosis affects mostly adults, who may experience signs and symptoms related to the organs affected such as skin rashes or characteristic red, blistering lesions, peptic ulcers, chronic diarrhea, joint pain or enlargement of the liver, spleen, or lymph nodes. Systemic mastocytosis may progress slowly or may be aggressive, causing organ dysfunction and, in rare cases, causing a form of leukemia.

Meconium ileus

A condition in newborn infants characterized by no stools in the first 24 to 48 hours of life

Megakaryocytes

Large cells in the bone marrow that produce blood platelets

Meninges

Layers of tissue that surround the brain and spinal cord

Mesothelioma

Rare cancer of the membranes that cover the outside of internal organs and line body cavities, including the chest (pleural mesothelioma), abdominal cavity (peritoneal mesothelioma), and the heart (pericardial mesothelioma)

Metabolism

Rare cancer of the membranes that cover the outside of internal organs and line body cavities, including the chest (pleural mesothelioma), abdominal cavity (peritoneal mesothelioma), and the heart (pericardial mesothelioma)Chemical reactions that occur in living organisms to convert one substance into another or produce energy

Metabolite

Product of chemical or biological processes in the body

Metastasis

Spread of cancer from its site of origin to distant sites

Microaerophilic

Living or occurring in a reduced-oxygen environment

Microcephaly

a birth defect in which a baby’s head is much smaller than expected and the brain is underdeveloped; this condition can occur because a baby's brain stops developing during pregnancy or stops growing after birth. A more serious, extreme form called severe microcephaly can occur during pregnancy when a baby's brain does not develop properly or begins to develop but then stops. Babies born with microcephaly can have several other issues, such as developmental delays, intellectual disabilities, hearing loss, problems with vision, and seizures.

Microcytic

Smaller than normal red blood cells

Microorganism

Also known as: Microbe

Life form that is not visible to the naked eye such as bacteria, fungi, parasites, and viruses

Mole

a growth on the skin comprised of a cluster of skin cells that produce the skin pigment melanin (melanocytes); a mole is often raised and dark in color.

Monoclonal antibody

Antibody produced by or derived from a single type (clone) of plasma cell

Monoclonal cells

Group of cells derived from a single type (clone) of cell; the cells formed are identical.

Monoclonal gammopathy
 
Monocyte

Leukocyte (white blood cell) that functions in the ingestion of bacteria and other foreign particles. Monocytes make up 5-10% of the total white blood cell count.

Musculoskeletal

Pertaining to system of bones, muscles, joints, and associated tissues (e.g., ligaments and tendons) of the body involved in the maintenance of body form and movement

Mutation

Change in the genetic structure (DNA); it may occur spontaneously or be induced (e.g., by radiation, drugs, or certain mutagenic chemicals).

Mycobacteria

A diverse group of rod-shaped bacteria that include Mycobacterium tuberculosis (which causes tuberculosis) and Mycobacterium leprae (which causes leprosy) and more than 100 different species found in the environment; the environmental mycobacteria may be referred to as nontuberculous mycobacteria (NTM), mycobacteria other than tuberculosis (MOTT), and/or atypical mycobacteria.

Myelin

Also known as: Myelin sheath

The fatty covering that insulates nerve fibers

Myelin sheath

Also known as: Myelin

The fatty covering that insulates nerve fibers

Narcolepsy

A chronic condition characterized by sudden uncontrolled sleep spells during the day

Nasopharynx

The area at the back of the nasal passages and above and behind the soft palate

Neonate

Newborn in its first month of life

Neoplasm

Also known as: Tumor


Growth of tissue characterized by uncontrolled cell proliferation; benign or malignant, localized or invasive

Nephrotic Syndrome

Damage to the glomeruli capillaries in the kidneys' filtering units, the nephrons; it leads to the loss of albumin and other proteins into the urine.

Neuroendocrine

1. Pertaining to the interaction between the nervous system and glands that produce hormones
2. Relating to or involving cells that produce hormones in response to the stimulation of nerves or the nervous system

Neurofibrillary tangles

A collection of twisted protein filaments found within nerve cells in the brains of people with Alzheimer’s disease

Neurologic

Pertaining to nerves and the nervous system, including the brain and spinal cord

Neutropenia

Decreased number of neutrophils, a type of white blood cell

Neutrophil

Also known as: Granulocyte


Normally the most abundant type of white blood cell in healthy adults

Next Generation Sequencing

Also known as: Next-gen sequencing; NGS

A type of laboratory test method that rapidly sequences large amounts of DNA; sequencing determines the order of DNA building blocks (nucleotides) in a person's genetic code. Changes in the building blocks (mutations) in the regions of DNA that are responsible for making proteins can lead to genetic disorders. Next-gen sequencing can look for mutations in any of the protein-producing regions of DNA, instead of looking for just a few specific mutations. In healthcare, this method may be used to help identify inherited or acquired genetic diseases (e.g., cancers), especially those caused by less common mutations.

Next-gen sequencing

Also known as: Next-gen sequencing; NGS

A type of laboratory test method that rapidly sequences large amounts of DNA; sequencing determines the order of DNA building blocks (nucleotides) in a person's genetic code. Changes in the building blocks (mutations) in the regions of DNA that are responsible for making proteins can lead to genetic disorders. Next-gen sequencing can look for mutations in any of the protein-producing regions of DNA, instead of looking for just a few specific mutations. In healthcare, this method may be used to help identify inherited or acquired genetic diseases (e.g., cancers), especially those caused by less common mutations.

NGS

Also known as: Next-gen sequencing

A type of laboratory test method that rapidly sequences large amounts of DNA; sequencing determines the order of DNA building blocks (nucleotides) in a person's genetic code. Changes in the building blocks (mutations) in the regions of DNA that are responsible for making proteins can lead to genetic disorders. Next-gen sequencing can look for mutations in any of the protein-producing regions of DNA, instead of looking for just a few specific mutations. In healthcare, this method may be used to help identify inherited or acquired genetic diseases (e.g., cancers), especially those caused by less common mutations.

Non-palpable

Not perceivable by touch

Normal flora

Microorganisms that live harmlessly on or in the body and do not cause disease unless the normal protective barriers (skin, mucosa) are compromised

NSAIDs

Also known as: Non-Steroidal Anti-Inflammatory Drugs


Group of painkillers that includes drugs such as ibuprofen and aspirin; they reduce fever as well as decrease pain and inflammation; can cause side effects such as stomach ulcers

Nucleus

The structure in cells that contains the chromosomes, genes, DNA.

Nutrient Medium
Also known as: Media
 
Material that provides the proper nutritional environment to promote the growth of microorganisms
Oligoclonal bands

Discrete bands observed on an electrophoretic gel as a result of a patients sample being analyzed by protein electrophoresis

Oncogene

Genetic material that is able to produce a malignant change in a cell; several have been identifited in human tissue as potential causes of cancer. Certain oncogenes may play a role in normal growth and development; if they are damaged or mutated, cancer may result.

Opportunistic Infection

Infection that affects people with suppressed immune systems

Oral

Pertaining to the mouth

Organ

A specific stucture in the body that performs one or more functions, such as the heart, lungs or liver

Osteoblast

Specialized bone cell that produces and deposits the material (mostly collagen) that forms new bone tissue

Osteoclast

Specialized bone cell that secretes enzymes that break down bone tissue; the cell then resorbs the dissolved bone material.

Osteomalacia

A bone disease that occurs in adults when a prolonged period of vitamin D deficiency results in soft, weak bones; when this condition occurs in childhood, it is called rickets.

Ova

Also known as: Ovuml


Egg

Over-expressed

Increased level (amounts) of a gene that results in the production of more than the normal amount of protein

Ovum

Also known as: Ova (plural)


Egg

Oxidative Stress

Damage to cells in the body caused by free radicals; free radicals, groups of atoms containing an oxygen atom and a free electron, can damage and sometimes destroy cells.

Paget Disease

1) The most common use of the term refers to a bone disorder in which bone is formed and broken down excessively, resulting in weakened bones. This condition can cause bone pain, deformed bones, arthritis, and numerous fractures.

2) Other, less common uses of the term refer to rare forms of cancer involving the nipple of the breast or the skin of other areas such as the perianal region, penis, or vulva (also termed extramammary).

Pallor

Pale skin color

Pandemic

An epidemic that occurs over a wide geographic area (across continents)

Paraganglioma

tumor that releases excess hormones called catecholamines (e.g., dopamine, epinephrine (adrenaline), norepinephrine and their metabolites, such as metanephrines) and usually occurs somewhere in the abdomen but outside the adrenal glands

Paramecium

Any of a genus (Paramecium) of ciliate chiefly freshwater protozoans that have an elongate body rounded at the anterior end and an oblique funnel-shaped buccal groove bearing the mouth at the extremity.

Parasite

One of the four major groups of microorganisms (bacteria, viruses, fungi, and parasites) that may live freely in nature, live on another organism without harming it, or live at the expense of the host organism

Parenteral

Administration of a substance (e.g., a drug) by injection (under or through the skin) or intravenously but not through the digestive system (not enterally)

Paresthesia

numbness, tingling, or prickling; an alteration in sensation

Parietal

1) Of or pertaining to the cells that line a cavity, such as the chest or abdomen;

2) A specialized cell in the stomach that makes acid to help in food digestion, as well as intrinsic factor, which is needed to absorb vitamin B12

Paroxysmal choreoathetosis

A condition characterized by involuntary, intermittent, and irregular movements of facial muscles and limbs

Pathogen

Organism that causes disease

Pathogenic

Disease-causing

Pathologist

A physician who diagnoses and characterizes disease by examining a patient’s tissues, blood, and other body fluids. Pathologists work in two broad areas:

Anatomic pathology is the examination of the physical appearance and microscopic structure of tissues. Anatomic pathologists look at biopsies and organs removed at surgery (surgical pathology) as well as cells that are collected from brushings or body fluids (cytology). They also perform autopsies to investigate the cause of death (autopsy pathology).

Clinical pathology deals with the measurement of chemical constituents of blood and other body fluids (clinical chemistry), analysis of blood cells (hematology), identification of microorganisms (microbiology), and the collection, preparation and use of blood for transfusion (transfusion medicine). Clinical pathologists direct the laboratories that perform these tests and provide consultation to other doctors on the significance of test results.

Pericardium

Sac-like membrane that surrounds the heart and the base of the blood vessels that lead into it

Peripheral nervous system

All parts of the nervous system except the brain and spinal cord

Peritoneum

Membranes that cover the abdominal cavity and the outside of abdominal organs

pH

Measurement of the acidity or alkalinity of a substance. A pH of 7.0 is neutral. A substance with a pH less than 7.0 is an acid, with increasing acidity as the pH decreases toward zero. Likewise, a substance with a pH greater than 7.0 is a base (alkali), with increasing alkalinity as the pH moves toward 14.0.

Phenotype

The observable physical or biochemical characteristics of a person, as determined by both their genetic makeup and environmental influences

Pheochromocytoma

tumor located in one or both of the adrenal glands that releases excess hormones called catecholamines (e.g., dopamine, epinephrine (adrenaline), norepinephrine and their metabolites, such as metanephrines)

Phospholipid

A substance in the body that contains both lipid (fat) and phosphorous; phospholipids are found in all cells throughout the body because they are a major component of the cell membrane, the outermost layer of a cell.

Pituitary gland

Pea-sized gland located in the center of the head behind the sinus cavity at the base of the brain; the pituitary consists of two parts that produce different hormones: 1) in the anterior portion, growth hormone (GH), adrenocorticotropin (ACTH), thyroid-stimulating hormone (TSH), lutenizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL) are produced; 2) in the posterior portion, oxytocin and antidiuretic hormone (ADH) (produced in the hypothalamus) are stored for release.

Placenta

The organ that connects a pregnant woman with her developing baby in the uterus; blood from the mother and baby do not mix directly, but a thin membrane within the placenta allows nutrients from the mother to pass to the baby and waste products to pass from the baby to the mother for elimination.

Plaque

1. Deposit on the inner arterial walls in atherosclerosis
2. Flat, raised patch on the skin or mucous membrane
3. Deposit of saliva and bacteria on teeth that encourages the development of caries

Plasma

Straw-colored, fluid part of blood and lymph

Plasma cell

Mature lymphocyte (B cell) that produces and secretes antibodies

Pleura

Also known as: Pleurae (plural)


One of the two membranes that surrounds each lung and lines the chest cavity

Pleurae

Also known as: Pleura


One of the two membranes that surrounds each lung and lines the chest cavity

Pneumonitis

An inflammation of the lungs; usually caused by a hypersensitive allergic reaction to repeated exposure to organic particles such as molds, grain dust, and chemicals

Polyclonal antibody

Antibody produced by or derived from many types (clones) of plasma cells

Polycythemia

Increase in the number of erythrocytes (red cells, RBCs) in the blood

Polymer

A large molecule consisting of multiple identical or similar chemical units that are linked together

Polymorphic

Gene having many different possible forms (alleles)

See also: Polymorphism

Polymorphism

Inherited person-to-person variation in the genetic code sequence within a specified DNA segment or gene

See also: Polymorphic

Polymyalgia Rheumatica

A disease that causes pain and weakness in the neck, shoulder muscles and pelvis, and morning stiffness. It commonly affects people over 50 years of age, especially women.

Polyp

A growth, such as on the lining of the mouth or intestines, that is usually benign; examples include uterine polyps and colorectal polyps

Posterior

At or toward the back

Precursor

1. one that comes before or gives rise to another
2. in chemistry, one substance that comes before or gives rise to another often more stable substance

Presumptive

Based on reasonable evidence or assumption; based on early, preliminary or partial results

Prevalence

The number of people with a particular disease at any given time in a population

Preventive Medicine

That branch of medicine concerned primarily with the prevention of disease

Prion Protein

An infectious agent (not bacteria or virus) that is an irregular form of a normal protein; prion proteins cause a variety of infections, including Mad Cow Disease and Creutzfeld-Jacob disease. Prion proteins are thought to induce normal brain proteins to assume an irregular shape, rendering them dysfunctional.

Prognosis

1) prediction about the course or outcome of a disease or illness
2) the likelihood of recovery from a disease or illness

Prophylaxis

(adj. Prophylactic)
1. Measure taken to prevent or protect against disease
2. Antibiotic prescribed to prevent infection

Prostatitis

inflammation of the prostate

Protein

Proteins are large molecules that form the structural part of most organs and make up enzymes and hormones that regulate body functions.

Pruritus

Also known as: Itch


An irritating skin condition that causes a desire to scratch

Pruritus

Also known as: Itch


An irritating skin condition that causes a desire to scratch

Purpura fulminans

Involves severe clotting throughout much of the body, ultimately causing death to the tissues. If not treated immediately, it is a life-threatening condition.

Pus

Collection of fluid, white blood cells, microorganisms, and cellular material that indicates the presence of an infected wound or abscess

Qualitative Test Results

Test results expressed in terms of the presence (positive) or absence (negative) of a property or condition

Quantitative Test Results

Test results expressed as numbers

Quantity Testing

Also known as: Antigen Testing


Quantity testing measures how much of a particular substance or analyte is present. This type of testing can measure amounts of coagulation factors, hormones, enzymes, and many other substances. It does not, however, evaluate how well the substance is working or performing its role in the body.

Random Blood Sample

A sample of blood collected at any time of the day

Random Urine Sample

A sample of urine collected at any time of the day; this type of sample may be used to detect the presence of various substances in the urine at one particular point in the day. Often, no special handling is required with these samples. Other types of urine samples are requested when special types of evaluations are required (see 24-hour urine sample and timed urine sample).

Raynaud phenomenon

Intermittent episodes of pallor, cyanosis (bluing), and redness in the fingers or toes due to constricted blood vessels; it is seen with a variety of conditions and is precipitated by exposure to cold and emotional stress. It may cause numbness, tingling, and burning.

Reagent

Substance used in performing a laboratory test

Recessive Gene

One of a pair of genes whose action is expressed only when two copies are present. For example, the gene for cystic fibrosis is recessive, and the disease will not occur if one normal gene is present.

Resorption

The process by which a substance, such as bone, is broken down into basic components and removed from that area of the body

Retina

sensing part of the eye that collects images from the lens and translates them to chemical signals that can be interpreted by the brain

Reye syndrome

A rare condition that causes degeneration of the brain and is characterized by vomiting, fever, accumulation of fat in the liver, swelling of kidneys and brain, disorientation and coma; often occurs in children and following another illness, such as the flu or chickenpox.

Rheumatic fever

Condition resulting from an inadequately treated or untreated infection with Group A streptococcus bacteria. It is a delayed immune response in which the body produces antibodies directed against itself (autoimmune). This can cause serious damage to heart valves and lead to symptoms such as swelling and pain in several joints, heart inflammation (carditis), skin nodules, rapid, jerky movements (Sydenham's chorea), and skin rash.

Rickets

A condition that occurs in childhood in which a severe lack of vitamin D causes weak, soft bones, delayed growth and skeletal development; when this condition occurs in adulthood, it is called osteomalacia.

RNA
Ribonucleic acid a nucleic acid present in all living cells. Its principal role is to act as a messenger carrying instructions from DNA for controlling the synthesis of proteins although in some viruses RNA rather than DNA carries the genetic information.
RNA

Also known as: Ribonucleic Acid


In a cell, a molecule that contains some of the genetic information of the cell involved in cellular processes and activities

RNA modification
RNA modifications are changes to the chemical composition of ribonucleic acid (RNA) molecules post-synthesis that have the potential to alter function or stability. An example of RNA modification is the addition of a methylated guanine nucleotide “cap” to the 5’-end of messenger RNAs (mRNAs).
SDS

Also known as: Shwachman-Diamond Syndrome

A rare congenital disorder characterized by exocrine pancreatic insufficiency, bone marrow dysfunction, and skeletal abnormalities; it is the second most common cause of inherited pancreatic insufficiency after cystic fibrosis.

Senile plaque

Areas of dead nerve cells and protein deposits in the brain

Sensitivity

In the clinical laboratory:
1. a test's ability to correctly identify individuals who have a given disease or disorder;
2. ability of a test to detect small amounts of a substance or to measure a reaction

Septicemia

Serious infection in which disease-causing organisms are present in the blood, usually resulting from spread of an infection from a specific site

Sequela

Abnormality resulting as a consequence of a disease, injury or treatment

Serotype

A group of related microorganisms, such as bacteria or viruses, that possess different antigens that are distinguished as unique by the immune system

Serum

The liquid portion of blood remaining after a clot forms

Serum Sickness

An allergic reaction to proteins in a foreign serum, usually in response to an injection; it is characterized by symptoms such as fever, skin rash, pain and swelling in one or more joints, and kidney damage

Shock

A condition in which blood flow is inadequate to keep critical organs performing properly; it is often recognized by markedly low blood pressure with evidence of poor function of the brain, kidneys, heart, and/or liver. It is a medical emergency that can lead to serious damage and/or death.

Shwachman-Diamond Syndrome

Also known as: SDS


A rare congenital disorder characterized by exocrine pancreatic insufficiency, bone marrow dysfunction, and skeletal abnormalities; it is the second most common cause of inherited pancreatic insufficiency after cystic fibrosis.

Sideroblastic Anemia

An iron disorder and form of anemia resulting from the inability to incorporate iron into hemoglobin in red blood cells (RBCs); it is characterized by the buildup of iron within developing RBCs resulting in abnormal RBCs called sideroblasts. Since the RBCs cannot develop normally, this condition causes anemia.

Sigmoidoscopy

Examination of the rectum and lower colon with a rigid or flexible lighted instrument

Sign

Evidence of a disease or condition perceived by a physician or person other than the patient

Somatic Cells

All body cells, except the reproductive cells

Specificity

In the clinical laboratory:
1. a test's ability to correctly exclude individuals who do not have the given disease or disorder;
2. a test's ability to correctly detect or measure only the substance of interest and exclude other substances

Spina bifida

A birth defect in which the bones of the spine do not close around the spinal cord (the continuation of brain tissue that normally is surrounded by the spinal bones); this opening may be covered by skin (also called spina bifida occulta, which means hidden), in which case there may be no or mild symptoms. In other cases, the skin does not cover the defect, allowing the covering of the brain and spinal cord, the meninges, to protrude out through the skin (meningocele) or, in some cases, to rupture, exposing the spinal cord itself (meningomyelocyle). These latter two examples may cause severe damage to the nerves of the legs and lower abdomen, causing paralysis and bowel and bladder malfunction.

Spirochete

Any of a group of spiral-shaped bacteria

Spleen

organ located in the abdomen that functions mainly to store blood cells, remove old blood cells from circulation, produce lymphocytes to fight infection, and filter foreign substances from the blood

Spondylitis

An inflammation of the vertebrae

Spore

1. Small, usually single-celled reproductive unit of some microorganisms such as fungi.
2. Form assumed by some bacteria that is resistant to heat, drying, and chemicals; an example of a disease caused by spore-forming bacteria is anthrax.

Sputum

Viscous material that is derived from the lower air passages such as the lungs and bronchi that may contain substances such as mucus, blood, pus and/or bacteria; it is not the saliva that is produced by the glands in the mouth.

Stage
  • In medicine, a defined period or phase in the development, progress or extent of a disease or condition; the process of determining the period or phase of a disease or condition. In cancer, the stage is the degree to which the cancer has grown or spread. Generally, lower numbers and/or letters mean less extensive stages.
  • (On a microscope) a raised and usually movable plate on which a slide or object is placed for examination.
  • A raised floor or platform.
Statins

A group of drugs that reduce the production of cholesterol and promote the clearance of low-density lipoprotein (LDL) from the blood by the liver.

Stem cells

Cells that are able to develop into many (or all) types of cells

Stenosis

A narrowing or constriction of a passageway in the body, such as in a blood vessel or spinal canal

Steroids

A group of chemicals derived from cholesterol that typically functions as hormones; common types of steroids include sex steroids (estrogen, progesterone, testosterone), glucocorticosteroids (cortisol, prednisone, dexmethasone), and mineralacorticosteroids (aldosterone).

Subcutaneous

Under the skin

Suprarenal gland

Also known as: Adrenal Gland


One of a pair of glands located above each kidney that secretes hormones directly into the bloodstream. Each gland has two parts that perform different functions.
1. The adrenal cortex produces and secretes hormones such as cortisol, aldosterone and sex steroids. They are involved in many different body functions.
2. The adrenal medulla produces and secretes catecholamines such as adrenaline (epinephrine) and norepinephrine.

Symptom

Evidence of a disease or condition experienced or perceived by a patient

Syncope

Fainting; loss of consciousness

Syndrome

A group of signs and symptoms that are associated with a physical or physiological anomaly; they represent a frame of reference, not a cause.

Systemic

Affecting the body as a whole, rather than individual parts

Temporal Arteritis

Chronic inflammation and damage of large arteries in the face and head; symptoms include headache, scalp tenderness, loss of vision, and facial pain.

Test

Also known as: Analyte


In the clinical laboratory, a substance from the body that is undergoing analysis.  In lay terms, often referred to as a "test."

Thrombocytopenia

Also known as: Thrombopenia


A decrease in the number of blood platelets

Thrombocytopenia

Also known as: Thrombopenia


A decrease in the number of blood platelets

Thromboembolism

Embolism— a condition in which material (tissue, fat, air, blood clot, etc.—called an embolus) travels through the bloodstream and then becomes lodged in a vein or artery and blocks the flow of blood through that blood vessel.

Thromboembolism—a blood clot (thrombus) that breaks free in the blood stream and blocks a blood vessel. This can occur in a vein (venous thromboembolism) or in an artery (arterial thromboembolism).

Thrombophilia

An inherited or acquired tendency to form blood clots within a vein or artery

Thrombosis

The formation of a blood clot within an artery or a vein.

Thrombotic Episode

The clinical signs and symptoms associated with a blood clot in a vein or artery. This can be a life-threatening event.

Thymus

Organ located behind the upper breastbone at the base of the neck that is part of the lymphatic and immune systems; disease-fighting white blood cells called T-cells develop and mature in the thymus before entering circulation. In humans, the thymus is normally active in childhood but becomes less active after puberty, eventually losing most immune activity by adulthood.

Thyroiditis

an inflamed thyroid

Timed Urine Sample

A sample of urine collected over a specified period of time; for a short collection (2 hours), you may be asked to do this at the laboratory. For longer collections (such as 12 hours or 24 hours), you will do this at home. At the beginning of the time period, empty your bladder and discard that urine. Note the time. Collect all urine voided for the specified period of time in the container provided. At the end of the time period, empty your bladder and ADD this urine to the container. Note the time. Bring all of the urine collected to the lab or doctor's office. If you miss collecting one or more voids, consult your doctor or the laboratory for further instructions. (See 24-hour urine sample)

Tissue
  • A collection of cells having a common purpose in the body, such as muscle tissue or kidney tissue.
  • A disposable piece of absorbent paper, used especially as a handkerchief or for cleaning the skin. (Tissue-Paper).
  • Rich or fine material of a delicate or gauzy texture.
  • An intricate structure or network made from a number of connected items.
Titer

In the clinical laboratory, titer is a unit of measurement. It is most often thought of as the lowest dilution of a substance in which a reaction takes place. It is usually expressed as a ratio (i.e., 1:20). For example, serum containing an antibody can be diluted with saline in a serial manner producing dilutions 1:5, 1:10, 1:20, 1:40, etc. If the lowest dilution that a reaction can still be detected between the antibody and the antigen it is directed against is 1:20, then that is the result of the antibody titer.

Topical

Applied to the surface of the skin

Toxemia of pregnancy

Also known as: Preeclampsia


A condition during pregnancy characterized by high blood pressure, protein in the urine, and fluid retention. If untreated, it can lead to eclampsia and convulsions that can be life-threatening to the mother and baby.

Toxemia of pregnancy

Also known as: Preeclampsia


A condition during pregnancy characterized by high blood pressure, protein in the urine, and fluid retention. If untreated, it can lead to eclampsia and convulsions that can be life-threatening to the mother and baby.

Toxic megacolon

A rare but serious, potentially life-threatening condition in which all or part of the colon progressively swells and becomes gangrenous, with tissue death resulting from lack of blood supply

Toxicity

Extent or degree to which something is poisonous

Toxin

Generally, anything that injures, is destructive, or can cause death; specifically, a poisonous substance made within living cells or organisms (plants or animals); may also include some medicines if taken in large amounts and certain metals

Tracer

In radiology, radioactive isotope (e.g., iodine-131) introduced into the body to allow biological structures to be seen as part of diagnostic X-ray techniques.

Translocation

(v. translocate) In genetics, movement of one section of a chromosome to a different position on another chromosome resulting in abnormal chromosome structure

Transplantation

Process of removing cells, tissue, or organ(s) from one body and inserting them into another body, especially using surgery

Transudate

Fluid that has leaked into a body cavity, due to an imbalance between the pressure within blood vessels (which drives fluid out) and the amount of protein in blood (which keeps fluid in); it is a clear fluid with low protein concentration and a limited number of white blood cells.

Tubular adenoma

Also known as: Adenomatous polyp


Abnormal growth of cells that form the glands in the lining of the colon or rectum; while benign, may become cancerous over time

Tubule

A long, thin hollow tube; in the kidney, a structure that connects to the glomerulus and helps the kidney retain needed small substances (such as water, electrolytes, glucose, calcium) while allowing elimination of waste products. Its contents eventually drain into the collecting system of the kidney as urine.

Tumor

Also known as: Neoplasm


Growth of tissue characterized by uncontrolled cell proliferation; benign or malignant, localized or invasive

Turner Syndrome

A disorder involving the X chromosomes in females. Normally, there are two functioning X chromosomes in every cell in the female body. In Turner syndrome, one of the X chromosomes is missing or is abnormal, or there are two normal X chromosomes present but in only some of the cells. Women with Turner syndrome usually have underdeveloped female sexual characteristics.

Tyrosine kinase

An enzyme that works by adding phosphate groups to various molecules, changing their function

Tyrosine kinase inhibitor

Drug used to treat certain types of cancer; it inhibits the action of tyrosine kinase, an enzyme involved in cell growth, thus impeding the growth of cancer cells.

U.S. Preventive Services Task Force

Also known as: USPSTF

an independent, volunteer panel of health professionals and experts. It regularly reviews the latest scientific evidence, such as research studies, to develop and update recommendations on various preventive services. The panel issues the findings as draft documents open for public comment before officially adopting them. The USPSTF is convened by the Agency for Healthcare Research and Quality (AHRQ) as authorized by the U.S. Congress.

Ulcer

A defect in the skin or lining of the mouth or intestines resulting from an infectious, malignant, or inflammatory process; examples include peptic (stomach) ulcers and mouth ulcers (canker sores)

Ulcerative colitis

A chronic disease of unknown cause that is characterized by inflammation, ulcers, and fluid collection in the lining of the colon; this condition may cause diarrhea with blood and/or mucus and stomach cramping and pain.

Unconjugated bilirubin

A fat-soluble form of bilirubin that is formed during the initial chemical breakdown of hemoglobin and, while being transported in the blood, is mostly bound to albumin.

Undifferentiated

Cells that are immature, embryonic or primitve, and have no specific form or specialized function are said to be undifferentiated

Uremia

A serious condition in which toxic waste products, normally excreted in the urine, build up in the blood; this is usually as a result of severe kidney disease or kidney failure.

Urethra

Tube through which urine passes from the bladder to outside of the body; in men, it is also the tube that runs through the penis and through which semen is dischargedTube through which urine passes from the bladder to outside of the body; in men, it is also the tube that runs through the penis and through which semen is discharged

Urinary casts

Protein shapes formed in the kidney tubules and released into the urine; they are roughly cylindrical with rounded ends and may have other components embedded in them such as red blood cells. Casts can be a sign of kidney disease.

USPSTF

Also known as: U.S. Preventive Services Task Force

an independent, volunteer panel of health professionals and experts. It regularly reviews the latest scientific evidence, such as research studies, to develop and update recommendations on various preventive services. The panel issues the findings as draft documents open for public comment before officially adopting them. The USPSTF is convened by the Agency for Healthcare Research and Quality (AHRQ) as authorized by the U.S. Congress.

Uveitis

Painful swelling and irritation of the uvea, the middle layer of the eye (the layer just beneath the white of the eye), which causes redness without itching; it is a serious condition that can lead to loss of vision.

Vaccine

A preparation designed to induce immunity to a specific disease

Venereal

Pertaining to or caused by sexual intercourse or genital contact

Vesicle

Also known as: Blister


A small raised area of the outer layer of the skin filled with a watery liquid

Viral load

Number of copies of viral genetic material

Virilization

Development of masculine physical characteristics in a woman

Virus

A microorganism consisting of a nucleic acid (either DNA or RNA) core and a protein coat. A virus requires a host cell to reproduce. It reproduces by infecting a host cell and taking over the nucleic acid of that host cell, making more virus nucleic acid and protein.

Viscosity

Resistance of a fluid (e.g., plasma, serum, cerebrospinal fluid) to flow; thickness or stickiness of a fluid

Vitamin

Any of a group of substances that, in very small amounts, are essential for normal growth, development, and metabolism. They cannot be synthesized in the body (with a few exceptions) and must be supplied by the diet.

Whole blood

Blood that is not separated into fluid and cellular components after removal from the body

Wild-type

The usual form of a gene in the general population, as opposed to mutant forms

X-linked recessive trait

A genetic trait that is apparent when all copies of the X-chromosome possess the gene; in men, this occurs when they inherit the trait from their mother, while women must inherit the trait from both parents. For this reason, X-linked recessive traits are almost always apparent only in men, while women are more commonly carriers of the trait.

X-linked trait

A genetic trait found on the X chromosome; women have two copies of this chromosome, while men have only one.

XXY disease

Also known as: XXY disease

A rare genetic condition in boys and men caused by an extra X chromosome. (Males normally have one X and one Y chromosome.) The presence of the extra X chromosome may or may not produce obvious signs and symptoms (usually in teens and adults), such as low testosterone, small penis and testicles, enlarged breasts, tall stature and/or behavioral, learning, speech or language disabilities. Most of these individuals are infertile.

Yeast

Small, one-celled fungus that reproduces by budding

Zika Virus
Zika virus (ZIKV) is a member of the virus family Flaviviridae. It is spread by daytime-active Aedes mosquitoes such as A. aegypti and A. albopictus. Its name comes from the Zika Forest of Uganda where the virus was first isolated in 1947.
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