Estimation of Creatinine Clearance from Serum Creatinine by Prediction Equations

Published in Clinical Pathology
Saturday, 26 August 2017 22:35
One can estimate GFR from age, sex, body weight, and serum creatinine value of a person from the following formula (Cockcroft and Gault):
 
 
Creatinine clearance in ml/min = (140 - Age in years) × (Body weight in kg)
                                                              (72 × Serum creatinine in mg/dl)
 
 
In females, the value obtained from above equation is multiplied by 0.85 to get the result.
 
It is recommended by National Kidney Foundation (USA) to calculate creatinine clearance by Cockcroft and Gault or other equation from serum creatinine value rather than estimating creatinine clearance from a 24-hour urine sample. This is because the latter test is inconvenient, time-consuming, and often inaccurate.

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